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Proceedings of the National Academy of Sciences of Belarus, Biological Series

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Morphology-function state of rat adipose-derived mesenchymal stem cells under the suppression of oxidative stress

Abstract

The influence of emoxipine on proliferative activity, viability in rat adipose-derived mesenchymal stem cells (MSCs) in culture, as well as the state in the MSCs of the antioxidant protection system was investigated. It is shown that when 0.00050.005 % concentrations of emoxipine in growth medium the proliferative activity of MSCs increased, did not influence the cell viability and reduced intracellular content of hydroperoxide and superoxide anion radicals. At concentrations of 0.010.25 % a emoxipine revealed the toxic effects on MSCs, that manifested itself in reduced proliferative activity and cell viability, increased intracellular content of superoxide anion radicals.
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ISSN 1029-8940 (Print)
ISSN 2524-230X (Online)