Эпигенетический контроль дифференцировки мезенхимальных стволовых клеток. Дифференцировка стволовых клеток в печени
https://doi.org/10.29235/1029-8940-2020-65-1-106-118
Аннотация
В обзоре приведены последние данные по эпигенетическому контролю дифференцировки мезенхимальных стволовых клеток, лежащего в основе эмбриогенеза и регенеративных процессов в организме. Эпигенетический контроль базируется на трех внутримолекулярных механизмах – метилировании ДНК, структурной модификации белков гистонов и действии микроРНК на посттранскрипционных и посттрансляционных уровнях. В качестве примера рассмотрены вопросы дифференцировки стволовых клеток в печени.
Об авторах
И. Д. ВолотовскийБеларусь
Волотовский Игорь Дмитриевич – академик, д-р биол. наук, заведующий лабораторией
ул. Академическая, 27, 220072, г. Минск
Д. А. Ермоленко
Беларусь
Ермоленко Дарья Андреевна – мл. науч. сотрудник
ул. Академическая, 27, 220072, г. Минск
Н. И. Горохова
Беларусь
Горохова Надежда Игоревна – мл. науч. сотрудник
ул. Академическая, 27, 220072, г. Минск
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