Evolutionary history of the MTG gene family in vertebrates
https://doi.org/10.29235/1029-8940-2019-64-4-391-402
Abstract
The highly conserved MTG gene family includes three homologs in vertebrates (MTG8, MTGR1, MTG16) encoding transcriptional corepressors, which are important in haemopoiesis, neurogenesis and epithelial stem cell differentiation. These genes are of particular interest because they are involved in translocations, associated with different types of cancer. Looking at how this gene family evolved might provide insights into history of its structural and functional diversification. We have performed a phylogenetic analysis of MTG nucleotide and protein sequences to examine the evolutionary events. The domain organization of MTG gene products was clarified, the mechanism of appearance of the first MTG gene was revealed and the ancestor taxon was determined. Also the mechanism of MTG gene family emergence was established. In addition, analysis of the rates of evolution acting on individual domains was made, and conservative positions within each gene of MTG family were determined.
About the Authors
A. I. Kavaleuskaya
Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus
Belarus
Belarus
Anna I. Kavaleuskaya – Junior Researcher
5/2, Academician V. F. Kuprevich Str., 220141, Minsk
T. V. Ramanouskaya
Belarusian State University
Belarus
Belarus
Tatsiana V. Ramanouskaya – P h. D . ( Biol.), Assistant Professor, Lecturer
4, Nezavisimosti Ave., 220030, Minsk
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