Preview

Proceedings of the National Academy of Sciences of Belarus, Biological Series

Advanced search

PROTEOME ANALYSIS OF BLOOD PLASMA OF BREAST CANCER PATIENTS

Abstract

Using two dimensional gel-electrophoresis method it was shown that blood plasma proteomic profiles are different for patients with various subtypes of breast cancer. Identified differences consist in the appearance of additional new proteins and changes in the expression of proteins present in norm on blood plasma proteomic maps of patients with breast cancer as compared to donors.

About the Author

Y. S. Bakakina
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus
Belarus
Ph. D. (Biophys.), Scientific Researcher


References

1. Ferlay, J., Shin, H. R., Bray, F., Forman, D., Mathers, C. and Parkin, D. M. (2008) ‟Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008”, International Journal of Cancer, vol. 127, pp. 2893-2917.

2. Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E. and Forman, D. (2011) ‟Global cancer statistics”, CA: A Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69-90.

3. Ludwig, J. A. and Weinstein, J. N. (2005) ‟Biomarkers in cancer staging, prognosis and treatment selection”, Nature Reviews Cancer, vol. 5, pp. 845-856.

4. Rifai, N., Gillette, M. A. and Carr, S. A. (2006) ‟Protein biomarker discovery and validation: the long and uncertain path to clinical utility”, Nature Biotechnology, vol. 24, pp. 971-983.

5. Dubovskaya, L. V., Kolesneva, E. V., Fedorovich, S. V., Denesevich, N. P. and Volotovskii I D. (2009) ‟Analysis of plasma proteome for diagnosis of chronic bronchitis”, Pul’monologiya [Pulmonology], no. 2, рр. 47-50.


Review

Views: 527


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1029-8940 (Print)
ISSN 2524-230X (Online)