ALUMINUM EFFECTS ON HUMAN ERYTHROCYTES
Abstract
It was shown that dose-depending aluminum accumulation in erythrocytes leads to aggravating of oxidative process in cells, decreasing activity of antioxidant enzymes, changing of lipids physical state on different depth of membrane and smoothing of microrelief of outer part of cell membrane. In vivo investigation revealed necessity of evaluation coefficient of relation concentration of aluminum and calcium (Ca/Al) in hair as prognostic index of aluminum ions influence on human organism.
About the Author
A. SKOROBOHATOVA
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus
Belarus
Belarus
References
1. IPCS. Aluminum Environmental Health Criteria 194. – Geneva: World Health Organization, 1997. – 417 p.
2. Dodge, G. T. The preparation and chemical characteristic of hemoglobin-free ghosts of human erythrocytes / G. T. Dodge, C. Mitchell, D. J. Hanahan // Arch. Biochem. Biophys. – 1963. – Vol. 100. – P. 119–130.
3. Sharman, W. M. Role of activated oxygen species in photodynamic therapy / W. M. Sharman, C. M. Allen, J. E. Van Lier // Meth. in Enzymol. – 2000. – Vol. 319. – P. 376–400.
4. Strauss, R. G. Malonaldehyde formation is not a suitable screening test to detect oxidation in human neutrophils / R. G. Strauss // J. Clin. Pathol. – 1988. – Vol. 34. – P. 800– 802.
5. TMA-DPH: a suitable fluorescence polarization probe for specific plasma membrane fluidity studies in intact living cells / J. G. Kuhry [et al.] // Cell Biophys. – 1983. – Vol. 5, N 2. – P. 129–140.
6. Phase fluctuation in phospholipid membranes revealed by laurdan fluorescence / T. Parasassi [et al.] // Biophys. J. – 1994. – Vol. 66, N 1. – P. 120–132.
7. Galla, H. J. Lateral diffusion in the hydrophobic region of membranes: use of pyrene excimers as optical probes / H. J. Galla, E. Sackmann // Biochim. Biophys. Acta. – 1974. – Vol. 339. – P. 103–115.
8. Гланц, С. Медико-биологическая статистика / С. Гланц; пер. с англ. – М.: Практика, 1998. – 459 с.
9. Лукьяненко, Л. М. Влияние алюминия на биофизические параметры мембран эритроцитов / Л. М. Лукьяненко, А. С. Скоробогатова, Е. И. Слобожанина // Вес. НАН Беларусi. Сер. бiял. навук. – 2010. – № 2. – С. 52–57.
10. In vitro effect of AlCl3 on human erythrocytes: changes in membrane morphology and functionality / L. M. Lukyanenko [et al.] // J. of trace elements in medicine and biology. – 2013. – Vol. 27. – P. 160–167.
11. Исследование оптических и наноструктурных металлиндуцированных изменений эритроцитарных мембран методами рассеяния и атомно-силовой микроскопии / А. Я. Хайруллина [и др.] // Оптика и спектроскопия. – 2011. – Т. 110, № 4. – С. 574–580.
12. Скальный, А. В. Биоэлементы в медицине / А. В. Скальный, И. А. Рудаков. – М.: ОНИКС 21 век, 2004. – С. 181–186.
13. Гресь, Н . А. Элементоз избытка алюминия / Н. А. Гресь, Е. И. Слобожанина, Е. Гузик. – Lambert Academic Publishing, 2014. – С. 78–84.
Review
Views: 542
Email this article 
