Features of the action of anxiolytics of natural and synthetic origin on inbred and outbred mice
https://doi.org/10.29235/1029-8940-2021-66-1-98-106
Abstract
The features of the anxiolytic action of natural (medicinal plant raw materials (MPR) and phytocomposition based on Patrinia intermedia, Valerian tablets) and synthetic (oleanolic acid) objects were studied. It was found that the MPR of Patrinia intermedia (1.7 mg/kg of saponins in terms of oleanolic acid) and the phytocomposition “Patrinia” (3.6 mg/kg of saponins in terms of oleanolic acid) reduced situational anxiety in socially active male ICR mice in an elevated plus maze, exceeding the anxiolytic effect of Valerian and oleanolic acid (the main aglicon of triterpene saponins in the roots and rhizomes of Patrima intermedia), used in doses of 5.0-20.0 mg/kg. It was revealed that «Patrinia» did not show activity in relation to the genetically determined pathologically increased basic anxiety in BALB / c mice in the “Cubic Box” test.
Keywords
Supporting agencies: The authors are grateful to the staff of the Department of Pharmacology and Pharmacy I. V. Zhebrakova, A. V. Malyavko, L. M. Zalashko, L. P. Gubina, Z. I. Krupskaya (Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus) and candidates of biological sciences L. V. Kukhareva and B. V. Anoshenko (Central Botanical Garden of the National Academy of Sci¬ences of Belarus) for assistance in organizing and conducting experiments
About the Authors
O. N. Savanets
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Belarus
Belarus
Oksana N. Savanets - Junior Researcher.
5/2, Academician Kuprevich Str., 220141, Minsk
E. V. Kravchenko
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Belarus
Belarus
Elena V. Kravchenko - Ph. D. (Biol.), Leading Resear-cher.
5/2, Academician Kuprevich Str., 220141, Minsk
P. T. Petrov
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus
Belarus
Belarus
Petr T. Petrov - Ph. D. (Chem.), Head of the Laboratory.
5/2, Academician Kuprevich Str., 220141, Minsk
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