MEMBRANE EFFECTS IN COMBINED IMPACT ON HUMAN ERYTHROCYTES OF AMYLOID FIBRILS AND LEAD IONS
Abstract
The effect of the combination of amyloid fibrils and lead acetate derived from lysozyme on human erythrocytes was studied. It was established that the complex effect of these two components on erythrocytes leads to a decrease in the activity of membrane-bound enzymes of acetylcholinesterase and NADH-methemoglobinreductase, a change in the microviscosity of the lipid bilayer of membranes, and an increase in the vesiculation of erythrocytes. The results indicate a more significant modification of the structural and functional state of erythrocyte membranes under the combined action of amyloid fibrils and lead ions on human erythrocytes compared with the control.
Keywords
Supporting agencies: Work supported by the Belarusian Republican Foundation for Fundamental Research (Project no. B13-К115).
About the Authors
G. P. Zubritskaya
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Ph. D. (Biol.), Researcher
27, Akademicheskaya Str., 220072
A. S. Skarabahatava
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Ph. D. (Biol.), Researcher
27, Akademicheskaya Str., 220072
L. M. Lukyanenko
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Ph. D. (Biol.), Deputy Director
27, Akademicheskaya Str., 220072
G. P. Gorbenko
V. N. Karazin Kharkiv National University, Kharkov
Ukraine
Ukraine
D. Sc. (Phys. and Math.), Professor
4, Maydan of Freedom, 61000
E. I. Slobozhanina
Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
Corresponding Member, D. Sc. (Biol.), Proffessor, Head of the Laboratory
27, Akademicheskaya Str., 220072
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