CIRCADIAN RHYTHM AND LIPID METABOLISM IN ANIMAL CELLS. PART I. MOLECULAR AND GENETIC ASPECTS OF THE BIOLOGICAL CLOCK
Abstract
This review (consisting of 2 parts) deals with the subjects of nature, properties, organization and functioning of the circadian rhythm and its importance in the regulation of physiological processes. Molecular and genetic aspects of the biological clock and its interrelation with lipid metabolism are also considered. Metabolic circadian rhythms are among the most important processes in an organism. It is established that there is a direct relationship between synchronicity and the processes of regulation of synthesis, absorption and secretion of lipids. The connection is observed at several levels: biochemical, molecular and genetic. Particular attention is paid to the influence of the circadian rhythm on the functioning and structure of skin and fat tissues which, in its turn, have autonomous circadian oscillators. In this case, the watch genes regulate the activity of numerous tissue-specific genes, thereby translating the daily information into physiologically significant signals. Considerable part of the work is devoted to the issues of desynchronizes, its causes and consequences. Diurnal disorders caused by external or internal factors can lead to disruption of the organism’s regulatory systems, which represents the development of metabolic disorders and tissue damage, which, in turn, can lead to maladaptation of the organism.
About the Authors
I. S. Sobolevskaya
Vitebsk State Medical University
Belarus
Ph. D. (Biol.), Assistant Professor
Belarus
Ph. D. (Biol.), Assistant Professor
O. D. Myadelets
Vitebsk State Medical University
Belarus
D. Sc. (Med.), Professor, Head of the Department
Belarus
D. Sc. (Med.), Professor, Head of the Department
E. S. Pashinskaya
Vitebsk State Medical University
Belarus
Ph. D. (Biol.), Assistant Professor
Belarus
Ph. D. (Biol.), Assistant Professor
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