ACTIVITY PROTEIN TRANSPORTERS IN HUMAN ERYTHROCYTES UNDER N-ACETYL-L-CYSTEINE ACTION
Abstract
It was established that in assessing transport glutathione conjugates from erythrocytes by the action N-acetylcysteine there is tendency to increase activity both ABCC1 and RLIP76. The latter, apparently, seems to make a certain contribution to the GSH-independent transport of xenobiotics from the erythrocytes. Using the fluorescent dye calcein was shown that transport activity of MRP1 during detoxification of xenobiotics, conjugated with glutathione, does not depend on the pool of free glutathione.
About the Author
J. S. KANASH
Institute of Biophysics and Cell Engineering of the National Academy of Sciences
Belarus
Belarus
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