vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2022-67-1-114-126vestib-797Research ArticleОБЗОРЫREVIEWSТрехмерная 3D-биопечать: основы технологии и ее использование в интересах биологии и медициныThree-dimensional 3D-bioprinting: the basis of technology and its application in the interests of biology and medicineВолотовскийИ. Д.VolotovskiI. D.

Волотовский Игорь Дмитриевич - академик, доктор биологических наук, профессор, главный научный сотрудник.

ул. Академическая, 27, 220072, Минск.

Igor D. Volotovski - Academician, D. Sc. (Biol.), Professor, Chief Researcher. Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus.

27, Akademicheskaya Str., 220072, Minsk.

volotovski@yahoo.comПинчукС. В.PinchukS. V.

Пинчук Сергей Владимирович - кандидат биологических наук, ведущий научный сотрудник.

ул. Академическая, 27, 220072, Минск.

Sergei V. Pinchuk - Ph. D. (Biol.), Leading Researcher. Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus.

27, Akademicheskaya Str., 220072, Minsk.

pinchuksv@mail.ruИнститут биофизики и клеточной инженерии НАН БеларусиInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus202202022022671114126Copyright © Волотовский И.Д., Пинчук С.В., 20222022Волотовский И.Д., Пинчук С.В.Volotovski I.D., Pinchuk S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/797

Настоящий обзор посвящен одной из актуальных проблем современных биологии и медицины, свидетелями бурного развития которых мы являемся. Представлена информация о сущности метода 3D-nечати, оборудовании, используемом для изготовления трехмерных биопродуктов, и природе расходных материалов - биочернил, наполнителей и клеток, которые в ходе биопечати превращаются в трехмерный продукт, характеризующийся жизнеспособностью и экспрессией специфических маркерных факторов соответствующих тканей и органов. Особый акцент сделан на перспективах использования при биопечати стволовых клеток наряду с самыми разнообразными клетками тканей и органов. Дано описание методов 3D-печати - струйного, экструзионного и лазерного и рассмотрены преимущества и недостатки каждого из них. Подробно описываются биочернила, их состав, использование в различных технологиях биопечати и стратегия подбора носителей и клеточного состава биочернил, определяющих жизнеспособность трехмерных структур и возможность их применения в клинической практике. Приводится краткий перечень достижений в области биопечати различных тканей организма и дается характеристика получаемых биопродуктов. Отмечаются значительный прогресс и перспективность исследований в данной области.

This review is devoted to one of the actual problem of modern biology and medicine, we are witnessing. The text provides information on 3D printing method, equipment that is used to manufacture of three-dimensional bioproducts and the nature of the consumable materials - bioinks, fillers and cells which during printing transform into three-dimensional bioproduct characterized by vitality and expression of specific marker factors of corresponding tissues and organs. Special emphasis in this review is made on prospects of use of stem cells which are along with a variety of cells of tissues and organs have found application in bioprinting. Three methods of bioprinting: inkjet, extrusion and laser are described. Advantages and disadvantages of each method are discussed. Bioinks, their properties applicability to various printing technologies and strategy selection of bioink and cell composition defining viability of three-dimensional structures and possibility of their application in clinical praxis are detailly described. Short list of achievements in the field of bioprinting of various organism tissues and the characteristics of the bioproducts obtained are given. Significant progress and promising research in the field of 3D bioprinting are marked.

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The authors declare that there are no conflicts of interest present.