vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2021-66-4-497-512vestib-782Research ArticleОБЗОРЫREVIEWSВзаимодействие полиамидоаминных дендримеров и амфифильных дендронов с липидными мембранамиInteraction of polyamidoamine dendrimers and amphiphylic dendrons with lipid membranesТереховаМ. М.TerehovaM. M.

Терехова Мария Михайловна – мл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Maria M. Terehova – Junior Researcher

27, Akademicheskaya Str., 220072, Minsk

maryterekhova@tut.byАбашкинВ. М.AbashkinV. M.

Абашкин Виктор Михайлович – мл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Viktar M. Abashkin – Junior Researcher

27, Akademicheskaya Str., 220072, Minsk

viktar.abashkin@gmail.comЖоглаВ. А.ZhoglaV. A.

Жогла Виктория Андреевна – мл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Victoriya A. Zhogla – Junior Researcher

27, Akademicheskaya Str., 220072, Minsk

victoriya.zhogla@gmail.comГалец-БуйИ. В.Halets-BuiI. V.

Галец-Буй Инесса Веславовна – канд. биол. наук, ст. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Inessa V. Halets-Bui – Ph. D. (Biol.), Senior Researcher

27, Akademicheskaya Str., 220072, Minsk

inessahalets@gmail.comЛозниковаС. Ж.LoznikovaS. Zh.

Лозникова Светлана Жоржевна – канд. биол. наук, ст. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Svetlana Zh. Loznikova – Ph. D. (Biol.), Senior Researcher

27, Akademicheskaya Str., 220072, Minsk

s_loznikova@mail.ruБрышевскаМ.BryshewskaM.

Брышевска Мария – д-р биол. наук, профессор, заведующий лабораторией

141/143, Pomorska, 90-236, г. Лодзь

Maria Bryshewska – D. Sc. (Biol.), Professor, Head of the Laboratory

141/143, Pomorska, 90-236, Lodz

marbrys@biol.uni.lodz.plИоновМ.IonovM.

Ионов Максим – д -р б иол. н аук, п рофессор

141/143, Pomorska, 90-236, г. Лодзь

Maksim Ionov – D. Sc. (Biol.), Professor

141/143, Pomorska, 90-236, Lodz

maksim.ionov@biol.uni.lodz.plВацуликоваИ.WaczulikovaI.

Вацуликова Ивета – д-р биол. наук, профессор

Šafárikovo námestie, 6, 81499, Братислава

Iveta Waczulikova – D. Sc. (Biol.), Professor

6, Šafárikovo námestie, 81499, Bratislava

iveta.waczulikova@fmph.uniba.skМажоральЖ.-П.MajoralJ.-P.

Мажораль Жан-Пьер – д-р хим. наук, профессор, заведующий лабораторией

205, route de Narbonne, 31077, Toulouse Cedex 4

Jean-Pierre Majoral – D. Sc. (Chem.), Professor, Head of the Laboratory

205, route de Narbonne, 31077, Toulouse Cedex 4

majoral@lcc-toulouse.frЩербинД. Г.ShcharbinD. G.

Щербин Дмитрий Григорьевич – д-р биол. наук, доцент, заведующий лабораторией

ул. Академическая, 27, 220072, г. Минск

Dzmitry G. Shcharbin – D. S c. (Biol.), A ssociate P rofessor, Head of the Laboratory

27, Akademicheskaya Str., 220072, Minsk

shcharbin@gmail.comИнститут биофизики и клеточной инженерии НАН БеларусиБеларусьInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of BelarusBelarusЛодзьский университетПольшаUniversity of LodzPolandУниверситет имени Я. А. КоменскогоСловакияComenius UniversitySlovakiaУниверситет ТулузыФранцияUniversity of ToulouseFrance202110112021664497512Copyright © Терехова М.М., Абашкин В.М., Жогла В.А., Галец-Буй И.В., Лозникова С.Ж., Брышевска М., Ионов М., Вацуликова И., Мажораль Ж., Щербин Д.Г., 20212021Терехова М.М., Абашкин В.М., Жогла В.А., Галец-Буй И.В., Лозникова С.Ж., Брышевска М., Ионов М., Вацуликова И., Мажораль Ж., Щербин Д.Г.Terehova M.M., Abashkin V.M., Zhogla V.A., Halets-Bui I.V., Loznikova S.Z., Bryshewska M., Ionov M., Waczulikova I., Majoral J., Shcharbin D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/782

Полиамидоаминные (ПАМАМ) дендримеры и амфифильные дендроны представляют собой вид наноматериалов, отличающихся гиперразветвленной структурой полимерных ветвей. В случае дендримеров дендроны ковалентно связаны в центральной фокальной точке. В отсутствие ковалентного связывания амфифильные дендроны с помощью гидрофобных взаимодействий формируют мицеллярные структуры. Данные наночастицы нашли широкое применение в биологии и медицине в качестве контрастных агентов, носителей лекарственных препаратов и генетического материала. Использование их в научной практике требует понимания механизмов взаимодействия с мембранами, которые являются основным препятствием для входа дендримеров в клетку. В данном обзоре обсуждены закономерности взаимодействия дендримеров и амфифильных дендронов с липидными мембранами. Описаны различные модели дендример-мембранных взаимодействий, позволяющие понять особенности вхождения дендримеров и амфифильных дендронов в клетки. 

Polyamidoamine (PAMAM) dendrimers and amphiphilic dendrons are one of the types of nanomaterials characterized by a hyperbranched structure of polymer branches. In the case of dendrimers, the dendrons are covalently linked at the central focal point. In the case of amphiphilic dendrons, dendrons are non-covalently linked by hydrophobic interactions, forming micellar structures. These nanoparticles are widely used in biology and medicine as contrast agents, carriers of drugs and genetic material. Their use in scientific practice requires an understanding of the basic mechanisms of their interaction with membranes – the main obstacle to the entry of dendrimers into the cell. This review discusses the regularities of the interaction of dendrimers and amphiphilic dendrons with lipid membranes. Various models of dendrimer-membrane interactions are described as the basis for the penetration of dendrimers and amphiphilic nanoparticles into cells. Keywords: polyamidoamine dendrimers, amphiphilic dendrons, lipid membranes, cells, antitumor therapeutics, antibacterial agents, diagnostics, genetic therapy.

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The authors declare that there are no conflicts of interest present.