vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2019-64-4-499-512vestib-625Research ArticleОБЗОРЫREVIEWSРезидентные стволовые и прогениторные клетки сердца: морфофункциональные свойства и перспективы практического использованияResident and progenitor stem cells of the heart: morphology and f unction properties and prospects for practical applicationВолотовскийИ. Д.VolotovskiI. D.

Волотовский Игорь Дмитриевич – академик, доктор биологических наук, профессор, заведующий лабораторией

ул. Академическая, 27, 220073, г. Минск

Igor D. Volotovski – Academician, D. Sc. (Biol.), Professor, Head of the Laboratory

27, Akademicheskaya Str., 220073, Minsk

volotovski@yahoo.comИнститут биофизики и клеточной инженерии НАН БеларусиInstitute of Biophysics and Cell Engineering201907112019644499512Copyright © Волотовский И.Д., 20192019Волотовский И.Д.Volotovski I.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/625

Проведен анализ литературных данных по одной из актуальных проблем современной клеточной биофизики и биотехнологии – стволовым клеткам сердца, участвующим в процессах репарации сердечной мышцы после ее повреждения в результате инфаркта миокарда. Рассмотрены биологические свойства и потенциальная способность резидентных мезенхимальных и прогениторных клеток сердца участвовать в репарационных процессах поврежденных кардиомиоцитах (КМЦ). Приводятся последние данные по испытаниям репарационной активности указанных клеток и их комбинаций на экспериментальных животных и пациентах. Обсуждаются подходы для повышения эффективности клеточных методов репарации поврежденных КМЦ.

The analysis of literature data on one of the actual problem of modern cell biophysics and biotechnology dealing with mesenchimal stem cells and cordial progenitor cells taking part in reparation of myocardium after its injury and first of all after myocardial infarction was done. Biological properties and potential ability of these cells in reparation processes of myocardium are considered. The recent data on experiments using experimental animals and patients are given. The approaches to increase the efficacy of сell technologies in treatment of injured cardiomyocytes are discussed.

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The authors declare that there are no conflicts of interest present.