vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2019-64-4-391-402vestib-471Research ArticleСтатьиЭволюционная история генов семейства MTG у позвоночныхEvolutionary history of the MTG gene family in vertebratesКовалевскаяА. И.KavaleuskayaA. I.

Ковалевская Анна Игоревна – младший научный сотрудник

ул. Академика В. Ф. Купревича, 5, корп. 2, 220141, г. Минск

Anna I. Kavaleuskaya – Junior Researcher

5/2, Academician V. F. Kuprevich Str., 220141, Minsk

bio.ovcharovaa@gmail.comРомановскаяT. В.RamanouskayaT. V.

Романовская Татьяна Владимировна – кандидат биологических наук, доцент, преподаватель

пр. Независимости, 4, 220030, г. Минск

Tatsiana V. Ramanouskaya – P h. D . ( Biol.), Assistant Professor, Lecturer

4, Nezavisimosti Ave., 220030, Minsk

 

romanovskaya.t@mail.ruИнститут биоорганической химии НАН БеларусиInstitute of Bioorganic Chemistry of the National Academy of Sciences of BelarusБелорусский государственный университетBelarusian State University201907112019644391402Copyright © Ковалевская А.И., Романовская T.В., 20192019Ковалевская А.И., Романовская T.В.Kavaleuskaya A.I., Ramanouskaya T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/471

Высококонсервативное генное семейство MTG у позвоночных включает три гомолога – MTG8, MTGR1, MTG16, которые кодируют транскрипционные корепрессоры, играющие важную роль в гемопоэзе, нейрогенезе и дифференцировке эпителиальных стволовых клеток. Эти гены являются чрезвычайно важными, потому что они способны вовлекаться в транслокации, ассоциированные с различными типами рака. Изучение эволюции этого семейства способно пролить свет на то, как происходила их структурно-функциональная дивергенция. Для изучения эволюции этого генного семейства был проведен филогенетический анализ нуклеотидных и аминокислотных последовательностей, выяснена доменная организация продуктов генов семейства MTG, определен механизм появления первого гена MTG и таксон – родоначальник этого гена. Кроме того, установлен механизм экспансии генного семейства, проведен анализ скоростей эволюции, действующей на отдельные домены белков семейства MTG, и определены консервативные позиции внутри каждого гена.

The highly conserved MTG gene family includes three homologs in vertebrates (MTG8, MTGR1, MTG16) encoding transcriptional corepressors, which are important in haemopoiesis, neurogenesis and epithelial stem cell differentiation. These genes are of particular interest because they are involved in translocations, associated with different types of cancer. Looking at how this gene family evolved might provide insights into history of its structural and functional diversification. We have performed a phylogenetic analysis of MTG nucleotide and protein sequences to examine the evolutionary events. The domain organization of MTG gene products was clarified, the mechanism of appearance of the first MTG gene was revealed and the ancestor taxon was determined. Also the mechanism of MTG gene family emergence was established. In addition, analysis of the rates of evolution acting on individual domains was made, and conservative positions within each gene of MTG family were determined.

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The authors declare that there are no conflicts of interest present.