vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2019-64-3-374-384vestib-442Research ArticleОБЗОРЫREVIEWSГибридные металл-органические наноцветы и их применение в биотехнологииHybride metall-organic nanoflowers and their applications in biotechnologyАбашкинВ. М.AbashkinV. M.

Viktar М. Abashkin – Junior researcher 

27, Akademicheskaya Str., 220072, Minsk, Republic of Belarus

 

viktar.abashkin@gmail.comГалец-БуйИ. В.Halets-BuI. V.

Галец-Буй Инесса Веславовна – кандидат биологических наук, научный сотрудни

ул. Академическая, 27, 220072, г. Минск

Inessa V. Halets-Bui – Ph. D. (Biol), Researcher 

27, Akademicheskaya Str., 220072, Minsk, Republic of Belarus

 

inessahalets@gmail.comДмитрукО. Г.DzmitrukV. G.

Дмитрук Ольга Геннадьевна – кандидат биологических наук, ведущий научный сотрудник 

ул. Академическая, 27, 220072, г. Минск

Volha G. Dzmitruk – Ph. D. (Biol.), Leading researcher 

27, Akademicheskaya Str., 220072, Minsk, Republic of Belarus

dmitruk.olga@gmail.comБрышевскаМ.BryszewskaM.

Брышевска Мария – доктор биологических наук, профессор, заведующий кафедрой 

ул. Поморска, 141/143, 90-236, г. Лодзь

Maria Bryszewska – D. Sc. (Biol.), Professor, Head of the Department 

141/143, Pomorska Str., 90-236, Lodz, Poland

maria.bryszewska@biol.uni.lodz.plЩербинД. Г.ShcharbinD. G.

Щербин Дмитрий Григорьевич – доктор биологических наук, доцент, заведующий лабораторией 

ул. Академическая, 27, 220072, г. Минск

Dzmitry G. Shcharbin – D. Sc. (Biol.), Professor, Head of the Laboratory 

27, Akademicheskaya Str., 220072, Minsk, Republic of Belarus

shcharbin@gmail.comОдабашиМ.OdabaşıM.

Одабаши Мехмет – доктор химических наук, профессор, заведующий кафедрой 

68100, Аксарай

Mehmet Odabaşı – D. Sc. (Chem.), Professor, Head of the Department 

68100, Aksaray, Turkey

modabasi@aksaray.edu.trАцетО.AcetÖ.

Ацет Омур – аспирант

68100, Аксарай

Ömür Acet – Postgraduate student 

68100, Aksaray, Turkey

omuracetbio@gmail.comОналБ.ÖnalB.

Онал Бурцу – аспирант

68100, Аксарай

Burcu Önal – Postgraduate student 

68100, Aksaray, Turkey

brconl33@gmail.comОздемирН.ÖzdemirN.

Оздемир Налан – доктор химических наук, профессор

38280, Талас, Кайсери

Nalan Özdemir – D. Sc. (Chem.), Professor 

Yenidoğan Mahallesi Turhan Baytop Sokak No. 1, 38280, Talas, Kayseri, Turkey

 

ozdemirn@erciyes.edu.trИнститут биофизики и клеточной инженерии НАН БеларусиInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of BelarusЛодзьский университетUniversity of LodzУниверситет АксарайAksaray UniversityУниверситет ЭрцийеErciyes University201916082019643374384Copyright © Абашкин В.М., Галец-Буй И.В., Дмитрук О.Г., Брышевска М., Щербин Д.Г., Одабаши М., Ацет О., Онал Б., Оздемир Н., 20192019Абашкин В.М., Галец-Буй И.В., Дмитрук О.Г., Брышевска М., Щербин Д.Г., Одабаши М., Ацет О., Онал Б., Оздемир Н.Abashkin V.M., Halets-Bu I.V., Dzmitruk V.G., Bryszewska M., Shcharbin D.G., Odabaşı M., Acet Ö., Önal B., Özdemir N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/442

Среди всего разнообразия современных наноматериалов можно выделить особый класс – наноцветы. Интерес ученых к данным наноструктурам обусловлен наличием у последних специфической топографии нанослоев, особое расположение которых позволяет получить значительно большее отношение площади поверхности к объему, чем у классических сферических наночастиц, что существенно увеличивает эффективность реакций на поверхности наноцветов. Основной способ применения наноцветов – использование их в качестве стабилизаторов ферментов. Последние представляют собой биосистемы с высокой активностью и субстратной специфичностью, но их использование ограничено высокой чувствительностью к среде, низкой воспроизводимостью экспериментальных результатов и наличием требований к комплексной очистке составляющих. Чтобы улучшить функционирование ферментов в различных условиях, разработаны органико-неорганические гибридные наноматериалы (название отражает связь неорганических компонентов в наночастицах с органическими материалами). Указанные наночастицы могут быть использованы в катализе, в качестве биосенсоров, а также для доставки лекарств. Это дало толчок развитию новой отрасли химии – химии гибридных наноматериалов, бурно развивающейся в настоящее время. Таким образом, изучение органико-неорганических гибридных нанокристаллов в области химии ферментных систем будет способствовать быстрому развитию бионаноматериалов и новых отраслей биотехнологии.

Among the variety of modern nanomaterials a special class – nanoflowers can be distinguished. These new nanostructures have induced the interest of scientists due to the topographic features of nanolayers, the special location of which allows a higher surface-to-volume ratio compared to classical spherical nanoparticles. Such topographic structure significantly increases the efficiency of surface reactions for nanoflowers. The main purpose of this type of nanomaterials is their use as enzyme stabilizers. Enzymes are biosystems with high activity and substrate specificity, but their use is limited by certain disadvantages, such as high sensitivity to the environment, low reproducibility of experimental results and requirements for complex purification of the components. To facilitate the functioning of enzymes in various conditions, organicinorganic hybrid nanomaterials have been developed, the name of which indicates that all components of inorganic nanoparticles are associated with organic materials. These nanoparticles have numerous promising applications in catalysis, as biosensors, and for drug delivery. Organic-inorganic hybrid nanoflowers have led to the development of a new branch of chemistry – the chemistry of hybrid nanomaterials, whose research is currently undergoing rapid development. Thus, the study of organic-inorganic hybrid nanocrystals can lead to new creative solutions in the field of chemistry of enzyme systems and the rapid development of bionanomaterials and new branches of biotechnology.

гибридные наноцветысинтезкатализбиосенсорыДанная работа поддержана Белорусским республиканским фондом фундаментальных исследований, гранты Б18ТЮБ-001, Б18ПЛШГ-004, Технологическим научным советом Турции (TUBITAK) номер гранта 118Z037, NAWA IAP, грант EUROPARTNER, No. PPI/APM/2018/1/00007/U/001, Государственной программой РБ “Инновационные биотехнологии – 2020”, мероприятие 43.This work was supported by grants Belarusian Republican Foundation for Fundamental Research (B18TUB-001, B18PLSHG-004, NAWA IAP, grant EUROPARTNER, No. PPI/APM/2018/1/00007/U/001, State Program “Innovative Biotechnologies-2020” grant number 43); by grant Scientific and Technological Research Council of Turkey (TUBITAK) number 118Z037.ReferencesKouassi, G. K. Examination of cholesterol oxidase attachment to magnetic nanoparticles / G. K. Kouassi, J. Irudayaraj, G. McCarty // J. Nanobiotechnol. – 2005. – Vol. 3, N 1. – P. 1. https://doi.org/10.1186/1477-3155-3-1Kouassi G. K., Irudayaraj J., McCarty G. 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The authors declare that there are no conflicts of interest present.