vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2019-64-2-190-197vestib-427Research ArticleСтатьиКомпьютерное моделирование аквапорин4-зависимого переноса воды через гематоэнцефалический барьерComputer simulation of aquaporin4-dependent water transfer across the hematoencephalic barrierБосяковаЕ. В.BasiakovaK. V.

Босякова Екатерина Владимировна – науч. сотрудник.

ул. Ф. Скорины, 24, 220114, г. Минск.

Katerina V. Basiakova– Researcher.

24, F. Skorina Str., 220114, Minsk.

basiakova.k.v@gmail.comТитовецЭ. П.TitovetsE. P.

Титовец Эрнст Петрович – д-р биол. наук, профессор, гл. науч. сотрудник.

ул. Ф. Скорины, 24, 220114, г. Минск.

Ernst P. Titovets– D. Sc. (Biol.), Professor, Chief researcher.

24, F. Skorina Str., 220114, Minsk.

eptitovets@gmail.comРеспубликанский научно-практический центр неврологии и нейрохирургии.Republican Research and Practical Center of Neurology and Neurosurgery.201917052019642190197Copyright © Босякова Е.В., Титовец Э.П., 20192019Босякова Е.В., Титовец Э.П.Basiakova K.V., Titovets E.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/427

Выполнено компьютерное моделирование AQP4-зависимого переноса воды через гематоэнцефалический барьер. Изучено влияние на объемный перенос воды изменений удельной плотности AQP4 и его поляризации на обменной поверхности капилляра. Установлено, что в зависимости от характера распределения аквапорина в глиальных мембранах, охватывающих капилляр, наблюдается изменение величины и направления объемного потока переносимой воды. Полученные результаты могут быть использованы для объяснения патогенеза развития отека головного мозга, а также при разработке способов фармакологической коррекции различных видов нарушения церебрального водного обмена.

A computational simulation of water transfer across the blood-brain barrier (BBB) has been carried out. In the developed model, AQP4 plays a kinetically limiting role in water transfer across the BBB. The effects of the AQP4 specific density changes and its polarized distribution have been studied in respect to the volumetric water transfer. It has been demonstrated that AQP4 density and polarization within the glial membranes enveloping the capillary can affect the volumetric flow and the sign of the water flux. The results might be used for elucidation of the pathogenic mechanism of cerebral edema and in development of the ways of pharmacological correction of the cerebral water metabolism disorders.

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The authors declare that there are no conflicts of interest present.