vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestib-253Research ArticleСтатьиИЗМЕНЕНИЕ ФИЗИКО-ХИМИЧЕСКИХ СВОЙСТВ ЛИПИДОВ В МЕМБРАНАХ ЛИМФОЦИТОВ ПРИ ДЕЙСТВИИ АМИЛОИДНЫХ ФИБРИЛЛ IN VITROTHE EFFECT OF AMYLOID FIBRILS ON THE CHANGES OF PHYSICAL AND CHEMICAL PROPERTIES OF MEMBRANE LIPIDS OF LYMPHOCYTES IN VITROВенскаяЕ. И.VenskayaE. I.

аспирант, мл. науч. сотрудник

Junior Scientific Researcher

e.i.rusina@mail.ruСкоробогатоваА. С.SkorobogatovaА. S.

канд. биол. наук, науч. сотрудник

Ph. D. (Biol.), Scientific Researcher Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus

sas.alesya@gmail.comЛукьяненкоЛ. М.LukyanenkoL. M.

канд. биол. наук, зам. директора по научной работе

Ph. D. (Biol.), Senior Scientific Researcher. Institute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus

lukyanenko@gmail.comИнститут биофизики и клеточной инженерии НАН БеларусиInstitute of Biophysics and Cell Engineering of the National Academy of Sciences of Belarus201616112016046265Copyright © Венская Е.И., Скоробогатова А.С., Лукьяненко Л.М., 20162016Венская Е.И., Скоробогатова А.С., Лукьяненко Л.М.Venskaya E.I., Skorobogatova А.S., Lukyanenko L.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/253

С помощью липофильных флуоресцентных зондов изучено влияние амилоидных фибрилл на состояние липидного бислоя мембран лимфоцитов человека. Полученные результаты позволяют заключить, что амилоидные фибриллы из лизоцима, взаимодействуя с лимфоцитами in vitro, вызывают изменение микровязкости липидного бислоя клеток.

In this work we study the effect of amyloid fibrils on lipid bilayer of human lymphocyte membranes using lipophilic fluorescent probes. The results suggest that amyloid fibrils of lysozyme could interact with lymphocytes in vitro and cause changes in the microviscosity of cells lipid bilayer.

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The authors declare that there are no conflicts of interest present.