vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"vestib-175Research ArticleСтатьиИнгибирование функциональной активности митохондрий печени крыс при ее токсическом поражении тетрахлорметаномInhibition of functional activity of rat liver mitochondria under acute intoxication by carbon tetrachlorideЗаводникИ. Б.ZavodnikI. B.zavodnik_il@mail.ruГродненский государственный университет имени Янки КупалыYanka Kupala Grodno State University20150706201604104110Copyright © Заводник И.Б., 20162016Заводник И.Б.Zavodnik I.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/175

, активность глутатионпероксидазы митохондрий, содержание оксида азота в плазме крови.

Acute carbon tetrachloride-induced rat liver damage (4 g/kg) after 24 h was accompanied by a significant reduction in succinate- and glutamate-dependent mitochondrial respiration rate in state 3 (by 65 %, and by 50 %, respectively). The acceptor control ratio and respiration control ratio approached to 1, reflecting the loss of respiration control. The mitochondrial alterations were associated with oxidation of intramitochondrial GSH, the inhibition of succinate dehydrogenase (complex II) and the rise of blood plasma nitric oxide level. Melatonin administration under CCl4-induced intoxication (three times at doses of 10 mg/kg) did not cause a pronounced recovery of mitochondrial functional activity, but prevented an increase in nitric oxide level in the blood plasma of intoxicated animals and enhanced the rate of succinate oxidation in state 3 by 30 % (p < 0.05).

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