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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vestib</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Национальной  академии наук Беларуси. Серия биологических наук</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the National Academy of Sciences of Belarus, Biological Series</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1029-8940</issn><issn pub-type="epub">2524-230X</issn><publisher><publisher-name>The Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vestib-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>К 85-ЛЕТИЮ НАЦИОНАЛЬНОЙ АКАДЕМИИ НАУК БЕЛАРУСИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANNIVERSARY OF THE FOUNDATION OF THE NATIONAL ACADEMY OF SCIENCES OF BELARUS</subject></subj-group></article-categories><title-group><article-title>Использование мезенхимальных стволовых клеток жировой ткани при лечении раневых дефектов кожных покровов в эксперименте</article-title><trans-title-group xml:lang="en"><trans-title>The application of mesenchymal stem cells from fat tissue for the treatment of wound defects of the skin in the experiment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранов</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranov</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">doc.e.baranov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Третьяк</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tretyak</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недзьведь</surname><given-names>М. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedzved</surname><given-names>M. K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Василевич</surname><given-names>И. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilevich</surname><given-names>I. B.</given-names></name></name-alternatives><email xlink:type="simple">ibce@ipb.org.by</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лобанок</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lobanok</surname><given-names>E. S.</given-names></name></name-alternatives><email xlink:type="simple">ibce@ipb.org.by</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Волотовский</surname><given-names>И. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Volotovski</surname><given-names>I. D.</given-names></name></name-alternatives><email xlink:type="simple">ibce@ipb.org.by</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Белорусский государственный медицинский университет</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>Институт биофизики и клеточной инженерии НАН Беларуси</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>07</day><month>06</month><year>2016</year></pub-date><volume>0</volume><issue>1</issue><fpage>60</fpage><lpage>67</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баранов Е.В., Третьяк С.И., Недзьведь М.К., Василевич И.Б., Лобанок Е.С., Волотовский И.Д., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Баранов Е.В., Третьяк С.И., Недзьведь М.К., Василевич И.Б., Лобанок Е.С., Волотовский И.Д.</copyright-holder><copyright-holder xml:lang="en">Baranov E.V., Tretyak S.I., Nedzved M.K., Vasilevich I.B., Lobanok E.S., Volotovski I.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vestibio.belnauka.by/jour/article/view/11">https://vestibio.belnauka.by/jour/article/view/11</self-uri><abstract><p>Представлены результаты экспериментального исследования, проведенного на крысах, по моделированию раневых дефектов кожных покровов и их лечению с применением аллогенных мезенхимальных стволовых клеток (МСК) из жировой ткани. Изучен характер течения экспериментальных ран при разных способах локальной трансплантации клеточной биомассы. Показано, что введение МСК в область раневых дефектов кожных покровов значительно сокращает сроки их заживления без каких-либо признаков инфицирования. Ускорение процесса эпителизации раны в группе животных после введения МСК связано, по всей видимости, с образованием грануляционной ткани и фибро-бластов при выделении из МСК ряда цитокинов и факторов роста. Полученные результаты рассматриваются в качестве нового научного подхода к лечению трофических язв и длительно незаживающих ран в клинической практике.</p></abstract><trans-abstract xml:lang="en"><p>The efficiency of the treatment of artificially made wound defects of rat skin using transplants from mesenchymal stem cell of fat tissue was investigated. It was found that above transplants considerably reduce the time of wound repair of the skin defects of experimental animals. The obtained data from the point of view of possibility of development of cell technology for the treatment of human diseases are discussed.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пальцев М. А. Биология стволовых клеток и клеточные технологии. М., 2009.</mixed-citation><mixed-citation xml:lang="en">Пальцев М. А. Биология стволовых клеток и клеточные технологии. М., 2009.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mizuno H., Nobita M. Uysal A. C. // Stem cells. 2012. Vol. 30. P. 804.</mixed-citation><mixed-citation xml:lang="en">Mizuno H., Nobita M. Uysal A. C. // Stem cells. 2012. Vol. 30. P. 804.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zuk P. 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