vestibИзвестия Национальной академии наук Беларуси. Серия биологических наукProceedings of the National Academy of Sciences of Belarus, Biological Series1029-89402524-230XThe Republican Unitary Enterprise Publishing House "Belaruskaya Navuka"10.29235/1029-8940-2026-71-2-116-124vestib-1010Research ArticleСтатьиПротивовоспалительные свойства экстрактов растений семейства RubiaceaeAnti-inflammatory properties of extracts from plants of the Rubiaceae familyПэнЮйсюаньPengYuxuan

Юйсюань Пэн – аспирант. Кафедра клеточной биологии растений и биоинженерии биологического факультета

ул. Курчатова, д. 10, 220030, г. Минск

 

Yuxuan Peng – Postgraduate Student. Department of Plant Cell Biology and Bioengineering, Faculty of Biology

10, Kurchatova Str., 220030, Minsk

archer6947@outlook.comБахметоваА. Ф.BakhmetavaA. F.

Бахметова Арина Фёдоровна – мл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Aryna F. Bakhmetava – Junior Researcher

27, Akademicheskaya Str., 220072, Minsk

bahmetovaarina@gmail.comhttps://orcid.org/0009-0005-9487-7202МыслейкаМ. А.MysleikaM. A.

Мыслейко Маргарита Алексеевна – магистрант

пер. Калинина, 10, 220049, г. Минск

Marharyta A. Mysleika – Master’s Student

10, per. Kalinina, 220049, Minsk

margaritamyslejko@gmail.comДемидчикВ. В.DemidchikV. V.

Демидчик Вадим Викторович – член-корреспондент, д-р биол. наук, профессор, гл. науч. сотрудник

ул. Академическая, 27, 220072, г. Минск

Vadim V. Demidchik – Corresponding Member, D. Sc. (Biol.), Professor, Chief Researcher

27, Akademicheskaya Str., 220072, Minsk

demidchik@botany.byБелорусский государственный университетBelarusian State UniversityИнститут экспериментальной ботаники имени В. Ф. Купревича Национальной академии наук БеларусиV. F. Kuprevich Institute of Experimental Botany of the National Academy of Sciences of BelarusУниверситет Национальной академии наук БеларусиBelarus202630042026712116124Copyright © Пэн Ю., Бахметова А.Ф., Мыслейка М.А., Демидчик В.В., 20262026Пэн Ю., Бахметова А.Ф., Мыслейка М.А., Демидчик В.В.Peng Y., Bakhmetava A.F., Mysleika M.A., Demidchik V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vestibio.belnauka.by/jour/article/view/1010

Виды семейства Мареновые (Rubiaceae) широко распространены преимущественно в тропических регионах. Они содержат различные алкалоиды, флавоноиды и другие активные соединения, обладающие выраженным терапевтическим действием в отношении широкого спектра заболеваний. В данном исследовании был проведен мета-анализ экспериментальных данных о терапевтических эффектах представителей Rubiaceae на основе информации из баз данных Cochrane, PubMed, Google Scholar и Web of Science. Поиск включал виды родов Gardenia, Hedyotis, Morinda, Nauclea и Paederia. Всего было проанализировано 348 работ, удалены дублирующие исследования, проведена фильтрация достоверности данных и наличия адекватных размеров выборок. Показано, что оценка уровня воспаления в большинстве работ проводилась на двух группах животных (группе, обработанной препаратами Rubiaceae, и модельной группе) с использованием тестов на присутствие провоспалительных цитокинов и экспрессию воспалительного гена NF-κB. Внутригрупповой анализ был направлен на изучение: 1) противовоспалительного действия растений различных родов семейства Мареновые; 2) противовоспалительного действия различных экстрактов. Результаты метаанализа показали, что экстракты растений семейства Rubiaceae оказывают выраженное противовоспалительное действие на животных моделях: в группе, обработанной ими, наблюдались более низкие уровни провоспалительных цитокинов (IL-1β, IL-6, TNF-α) и экспрессии NF-κB по сравнению с модельной группой воспаления (p < 0,05). Внутригрупповой анализ выявил, что экстракты растений родов Gardenia, Hedyotis и Morinda достоверно снижали уровни IL-1β и TNF-α, тогда как только растения рода Morinda оказывали выраженное ингибирующее действие по отношению к IL-6; водные, этанольные и терпеноидные экстракты демонстрировали значительную противовоспалительную активность. Установлено, что гетерогенность, обнаруженная в результате внутригруппового анализа и метарегрессии, в основном обусловлена межвидовыми различиями. Тесты Бегга и Эггера указали на наличие публикационной смещенности в отобранных исследованиях. Проведенное исследование показало, что необходимы дальнейшие эксперименты in vivo и in vitro для подтверждения противовоспалительного действия различных лекарственных растений семейства Rubiaceae.

Rubiaceae species are widely distributed, mainly concentrated in tropical regions. They contain various alkaloids, flavonoids, and other active compounds that have significant therapeutic effects on many diseases. In this study a meta-analysis of the existing experimental data on the therapeutic effects of Rubiaceae was conducted using Cochrane, PubMed, Google Scholar, and Web of Science databases for report retrieval. The search contained “Gardenia”, “Hedyotis”, “Morinda”, “Nauclea”, and “Paederia” species of Rubiaceae, which were used in animal inflammation models. A total of 348 papers were analyzed, duplicate studies were removed, data reliability and adequate sample sizes were filtered. Proinflammatory cytokines (PCs), and the expression of inflammatory gene NF-κB were used to evaluate the inflammatory levels in two animal models, the Rubiaceae-treated (RT) and Inflammation Model (IM). Subgroup analysis was used to explore: 1) the anti-inflammatory effects of different genera; 2) the anti-inflammatory effects of different extracts. The results from meta-analysis show that Rubiaceae extracts exert significant anti-inflammatory effects in animal models, with the RT group exhibiting lower levels of PCs (IL-1β, IL-6, TNF-α) and NF-κB expression than the IM group (p < 0.05). Subgroup analysis found that Gardenia, Hedyotis, and Morinda all significantly reduced IL-1β and TNF-α levels, while only Morinda had a notable inhibitory effect on IL-6; aqueous, ethanol, and terpenoid extracts all showed significant anti-inflammatory activity. Substantial heterogeneity was observed, which subgroup and meta-regression analyses identified as being primarily due to intergeneric differences. Begg’s and Egger’s tests indicated the presence of publication bias across the included studies. Further in vivo and in vitro experiments are therefore required to verify the anti-inflammatory effects of various medicinal plants of the Rubiaceae family.

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The authors declare that there are no conflicts of interest present.